You're killin' me Smalls is a meaning and origin of the phrase.
Smalls is from the 1993 baseball movie The Sandlot.The movie revolves around a boy named Scotty Smalls who moves into a new neighborhood and is taken under the wing of the local boys and taught to play baseball.
On two separate occasions in the film, Scotty Smalls displays his lack of knowledge about some part of childhood that the other boys think is essential.In the first case, the character asks if he wants a s'more.After a bit of back-and-forth, Ham exclaimed, "You're killing me, Smalls" and explained what a s'more is.When Smalls is offered chewing tobacco, he asks, "What do you do with it?" much to the irritation of his friends.The popularity of the character Ham helped cement the line in pop culture.
Smalls is an allusion to the movie, You're killing me, and can signify a range of emotions.Knowing exasperation can be used with flight delays.Smalls can say that air travel has its drawbacks, but that the delays are proving too much.Smalls can show affection for a child if they say, "I can't handle how adorable you are." The phrase is popular enough to be featured on t-shirt designs.