Education and Communications What is the most powerful treatment for acne? What is the most powerful treatment for acne? Isotretinoin is a powerful drug that's used to treat the most severe cases of acne. Your doctor may recommend this drug if you have severe acne that doesn't get better with other medications, including antibiotics. What is the number 1 acne brand? 1. Neutrogena Oil-Free Salicylic Acid Acne Fighting Acne Wash.Aug 5, 2020 Related Posts:FDA prescribe information, side effects, and uses of cefprozil.What is Linseed Oil used for in oil painting?What is the best over the counter treatment for teenage acne?What does bacterial acne look like?