The most effective antidepressant compared to placebo was the tricyclic antidepressant amitriptyline, which increased the chances of treatment response more than two-fold (odds ratio [OR] 2.13, 95% credible interval [CrI] 1.89 to 2.41).2018-04-03
Mixing antidepressants with alcohol, cocaine, Molly or other illegal drugs is never recommended. If you're taking medication for depression, it is important that you leave the drug alone and don't throw in any other substances that might prevent it from doing its job.2020-04-15
What is the best and safest antidepressant?
The investigators recommend sertraline as the best choice for an initial antidepressant because it is available in generic form and is therefore lower in cost. They further recommend that sertraline, instead of fluoxetine or placebo, be the new standard against which other antidepressants are compared.
Is fluoxetine a strong antidepressant?
Prozac, or fluoxetine, is a selective serotonin reuptake inhibitor (SSRI) and a widely used antidepressant. It is considered safe and effective in treating depression, anxiety, and obsessive compulsive disorder (OCD), and bulimia. Adverse effects include an increased risk of suicidal thoughts in some younger people.