Interleukin-17 (IL-17) induces the production of granulocyte colony-stimulating factor (G-CSF) and chemokines such as CXCL1CXCL1Growth-related oncogene (GRO), a member of the CXC chemokine subfamily, plays a major role in inflammation and wound healing. CXC chemokines have been found to be associated with tumorigenesis, angiogenesis, and metastasis.https://pubmed.ncbi.nlm.nih.gov › A growth-related oncogene/CXC chemokine receptor 2 autocrine and CXCL2 and is a cytokine that acts as an inflammation mediator.
What is human interleukin 17A antagonist?
Secukinumab is a fully human anti-IL-17A monoclonal antibody. Secukinumab showed efficacy in the treatment of moderate-to-severe plaque psoriasis in a randomized double-blind placebo-controlled phase II regimen finding study.
Is IL-17 an inflammatory cytokine?
IL-17A and IL-17F mediate their immunological function by inducing pro-inflammatory cytokine, anti-pathogenic peptide and chemokine secretion by responder cells. The release of these pro-inflammatory molecules triggers the recruitment of innate immune cells to the site of infection and elimination of the pathogen.
Does IL-17 activate macrophages?
Moreover, macrophages differentiated with IL-17 exhibited increases of TLR2 and TLR4 of 3- and 3.8-times, respectively, compared to M0 (Fig. 3a and b). These results suggest that macrophages differentiated with IL-17 express TLR2 and TLR4, which may contribute to the activation of macrophages.
What does IL-17A stand for?
Interleukin-17 (IL-17, also known as IL-17A) is a key cytokine that links T cell activation to neutrophil mobilization and activation. As such, IL-17 can mediate protective innate immunity to pathogens or contribute to the pathogenesis of inflammatory diseases, such as psoriasis and rheumatoid arthritis.Oct 1, 2016
What is the difference between IL-17A and IL-17F?
Despite the large number of double- positive cells in these models, IL-17F is dispensable for autoimmune tissue inflammation whereas IL-17A-deficient mice show reduced disease (Ishigame et al., 2009).
What is IL-17A ankylosing spondylitis?
IL-17 is a pro-inflammatory cytokine that plays critical roles within a network of cytokines and is a key contributor to tissue repair on barrier surfaces, anti-infective immune responses, and the pathogenesis of various inflammatory diseases, especially ankylosing spondylitis [3].
What is the difference between IL-17 and IL-17A?
IL17C shows only 23% homology with IL-17A, and unlike IL-17A, is expressed mainly by epithelial cells rather than immune cells. Much evidence links IL-17C to skin inflammation. Importantly, IL-17C is overexpressed in lesional skin of psoriatic (91, 92) and atopic dermatitis patients (93).Aug 2, 2018
How is IL-17 produced?
IL-17 is believed to be mainly produced by T helper 17 (Th17) cells, a unique helper T-cell subset different from Th1 and Th2 cells. Other subsets of T cells such as γδT and natural killer T (NKT) cells have also been found to produce IL-17 in response to innate stimuli.
What is an IL-17 inhibitor?
Secukinumab, ixekizumab and brodalumab are monoclonal antibody therapies that inhibit interleukin (IL)-17 activity and are widely used for the treatment of psoriasis, psoriatic arthritis and ankylosing spondylitis.
Is IL-17A pro-inflammatory?
IL-17A promotes inflammation by inducing various proinflammatory cytokines and chemokines, recruiting neutrophils, enhancing antibody production, and activating T cells. IL-17A expression is also augmented in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
Which interleukin is pro-inflammatory?
IL-12IL-12IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.https://en.wikipedia.org › wiki › Interleukin_12Interleukin 12 - Wikipedia, a pro-inflammatory interleukin, is a heterodimeric cytokine produced mostly by phagocytic cells in response to bacteria, bacterial products, and intracellular parasites, and to some degree by B lymphocytes.