If your results show higher than normal amounts or increased activity of complement proteins, it may mean you have one of the following conditions: Certain types of cancer, such as leukemia or non-Hodgkin lymphoma. Ulcerative colitis, a condition in which the lining of the large intestine and rectum become inflamed.16 Sept 2021
The CH50 is typically below normal. Up to 25% of patients with SLE, however, may have much more dramatic reductions in C4 levels, typically associated with significantly subnormal C3 levels and CH50.
What is a high complement total CH50?
A total complement measurement, also known as a total hemolytic complement or a CH50 measurement, checks how well the complement system is functioning. This test is usually ordered for people with a family history of complement deficiency and those who have symptoms of: RA. kidney disease.
What is a normal total complement?
Normal Results Total blood complement level: 41 to 90 hemolytic units. C1 level: 14.9 to 22.1 mg/dL.
What is low CH50?
CH50 is often decreased in SLE, glomerulonephritis and other immune complex diseases. A normal CH50 level indicates that all the components, C1 through C9, are present. However, individual complement factors may be depleted 50 to 80% without affecting CH50 activity. Depletion of alternative factors is not detected.
What does it mean when CH50 is high?
Increased levels of complement may indicate: Acute-phase immune response. Cancer. Ulcerative colitis.
What does complement 60 mean?
The complement system is a group of nearly 60 proteins that are in blood plasma or on the surface of some cells. The proteins work with your immune system and play a role to protect the body from infections, and to remove dead cells and foreign material.
What is the normal range for CH50?
Adult reference range is 42 to 95 U/mL. A low CH50 suggests the possibility of a complement factor deficiency.
What is the purpose of the total complement activity CH50 assay?
The total complement activity / CH50 (also known as CH100) is a screening assay for the activation of the classical complement pathway and it is sensitive to the reduction, absence and/or inactivity of any component of the pathway.
How does CH50 test work?
The test is based on the capacity of an individual's serum to lyse sheep erythrocytes coated with anti-sheep antibodies (preferably rabbit IgG). The individual's serum is diluted until the minimum concentration is reached that 50% of the sheep red blood cells are lysed, and that concentration is recorded as the CH50.