Your pathology report may include information about the rate of cell growth — what proportion of the cancer cells within the tumor are growing and dividing to form new cancer cells. A higher percentage suggests a faster-growing, more aggressive cancer, rather than a slower, “laid back” one.4 Nov 2021
What does low proliferation rate mean?
Doctors commonly use a measure called “Ki-67” to describe the proliferation rate. A low Ki-67 percentage means slowly dividing cells, and a high Ki-67 (over 20%) means quickly dividing cells.
What is considered a high Ki-67 score?
A result of less than 6% is considered low, 6-10% intermediate, and more than 10% is considered high. Ki-67: Ki-67 is a protein in cells that increases as they prepare to divide into new cells. A staining process can measure the percentage of tumor cells that are positive for Ki-67.4 Nov 2021
What does proliferation mean in cancer?
Cell proliferation is how quickly a cancer cell copies its DNA and divides into 2 cells. If the cancer cells are dividing more rapidly, it means the cancer is faster growing or more aggressive. The rate of cancer cell proliferation can be estimated by doing a Ki-67 test.8 Nov 2021
What does high proliferation index mean?
Diagnostic role of proliferation index In general, a high proliferation index suggests malignancy and high-grade tumors. Among solid tumors, the clinical significance of the proliferation index on breast cancer has been extensively studied.
How reliable is Ki-67?
Ki-67 assessed by using method A with a cut-off of 10% was a predictive marker for OS, as the hazard ratio (>10% vs. <=10%) in patients with chemotherapy was 0.48 with a 95% confidence interval of [0.19–1.19].19 Sept 2019
What does cell proliferation means?
Cell proliferation is the process that results in an increase of the number of cells, and is defined by the balance between cell divisions and cell loss through cell death or differentiation.
What is considered a high KI 67 score in lymphoma?
The mean Ki-67 PI ranged from 26.6% in indolent lymphomas to 97.6% in very aggressive lymphomas (P < 0.001). The index was <45% in 82.8% of indolent lymphomas and >45% in 85% of aggressive lymphomas (AUC = 0.877, P < 0.001).
Does a high KI 67 mean chemo?
Numerous studies have demonstrated that the expression of the human Ki-67 protein is associated with cell proliferation; therefore, increased Ki-67 levels in cancer tissue have been considered a poor prognostic factor, while also being a positive predictive factor for response to chemotherapy [2,3].28 Mar 2014