You may feel a small prick, kind of like getting a shot. Your blood will flow into a tube connected to the needle and into a bag, where it's kept until it's needed.
Is the needle for blood donation big?
To minimize shearing forces that irreversibly damage the red blood cells, a large needle (16 to 17 gauge) is used during the collection of blood. Moreover, a tourniquet may be tied around your upper arm to increase the pressure and flow of blood.
Does the plasma needle hurt?
Donating plasma shouldn't hurt. Donating plasma should feel the same as a regular blood donation. You might feel a stinging sensation when the needle is inserted, but after that, the staff will do its best to make sure that you're comfortable throughout the donation process.
How can I make my blood donation less painful?
Move slowly and carefully, taking care to sit and stand up slowly when you feel well enough. Drink plenty of fluids. If you do not feel better within a few hours consult your doctor or your local blood donation helpline.