Arts and Entertainment Can ibuprofen help with menstrual bleeding? Can ibuprofen help with menstrual bleeding? Ibuprofen Using an NSAID at the time of a period can decrease the amount of bleeding by 20-40%, and sometimes by even more if a woman normally has very heavy periods. NSAIDs also work great for relieving menstrual cramps. Related Posts:How do you stop bleeding from IUD?Can I take 600 mg of ibuprofen for toothache?What is the first period like after Mirena?Is ibuprofen more effective on an empty stomach?